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Bacillus subtilis 1

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Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 248-253 doi: 10.1007/s11684-011-0149-3

Abstract: Arterial remodeling in allografts eventually causes ischemic graft failure.This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including

Keywords： transplantation     chronic rejection     neointimal     immunology     arterial remodeling     allograft vasculopathy    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract: Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis.However, TFPISma mice had increased ferric chloride–induced arterial thrombosistogether, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 408-414 doi: 10.1007/s11684-009-0069-7

Abstract: Bone remodeling in orthodontic treatment has been one of the most concerned issues.The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual

Keywords： alveolus     remodeling     orthodontics     extraction    

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Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 3,   Pages 300-304 doi: 10.1007/s11465-009-0038-5

Abstract: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequency

Keywords： spatial kinematics     natural frequency     finite element method    

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Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 68-73 doi: 10.1007/s11684-007-0014-6

Abstract: The association of metabolic syndrome (MS) with arterial compliance in children and adolescents was exploredArterial compliance was measured using digital pulse wave analyzing method from the pulse trace machineThe arterial compliance of MS group was significantly lowered in children and adolescents, and with theincrease of the clustering of MS components, arterial compliance was gradually decreased.It was suggested that arterial compliance assessment in children and adolescents was important for early

Keywords： compliance assessment     correlation analysis     cardiovascular     clustering     HOMA-IR    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city

Mbakisya ONYANGO, Saliha Ammour MERABTI, Joseph OWINO, Ignatius FOMUNUNG, Weidong WU

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 291-299 doi: 10.1007/s11709-017-0419-5

Abstract:

Many transportation agencies lack sufficient funds to maintain and repair roads, which results into increased pavement maintenance cost. Pavement Management System (PMS) has demonstrated to be an essential tool for proper management of infrastructure and proper utilization of available funds. The University of Tennessee at Chattanooga utilized Micropaver software as PMS tool to conduct a pavement management analysis of principal arterials in the City of Chattanooga. The study used the City of Chattanooga pavement database to create the current and future pavement conditions. Maintenance and repair (M&R) planning analysis was also performed in order to determine the most cost-effective treatment and suggest the optimum utilization of funds for the city. An analysis of five budget scenarios was conducted for a five-year plan using the critical pavement condition index (PCI) method (ASTM D6433). Results show that the backlog elimination budget would be the best scenario because it increases the pavement condition and eliminates the backlog of major maintenance and repairs over the five-year period. The unlimited budget seems though ideal, it does not improve pavement condition. Maintaining current condition and limited budget scenarios would increase both the backlog and the total cost of maintenance and repairs over the analysis period.

Keywords： PMS     Micropaver     pavement budget     maintenance     rehabilitation    

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A dynamic signal coordination control method for urban arterial roads and its application Article

Guo-jiang SHEN,Yong-yao YANG

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 9,   Pages 907-918 doi: 10.1631/FITEE.1500227

Abstract: signal coordination method that takes account of the special traffic flow characteristics of urban arterialcorrelation degree based on a hierarchical structure and a method to divide the control area of urban arterial

Keywords： Urban arterial     Control subarea     Coordination control     Correlation degree     Fuzzy logic     Intelligent transportation    

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 60-67 doi: 10.1007/s11684-019-0694-8

Abstract: Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodelingfactor and plays an important role in chromatin remodeling for gene activation through its association

Keywords： BPTF     small molecule     epigenetics     non-small-cell lung cancer    

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Contemporary coronary artery bypass grafting

David P. Taggart

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 395-398 doi: 10.1007/s11684-014-0374-7

Abstract: The article also describes the evidence basis to support the use of more arterial grafts during CABG

Keywords： coronary artery bypass grafting (CABG)     coronary artery disease     left main     arterial grafts     internal mammary    

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Non-invasive continuous blood pressure monitoring: a review of current applications

Elena Chung, Guo Chen, Brenton Alexander, Maxime Cannesson

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 91-101 doi: 10.1007/s11684-013-0239-5

Abstract:

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

Keywords： áz technique     arterial tonometry     pulse transit time    

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Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Strategic Study of CAE 2007, Volume 9, Issue 4,   Pages 75-78

Abstract:

In this paper, on the basis of the constitutive relation theory which includes inner variables, with the general explicit description of incremental strain thermal-plastic constitutive relations and the specific incremental thermal-plastic constitutive relations, combining the simulation of X ray load and the tube responsing problem which is greatly important in practice, the self-contained equation group about the stress wave in the flexible material_steel composite shell problem is developed. Numerical simulations are carried out with the presented constitutive relations for explosive-filled sphere fracture problem and the results are analyzed.  The thickness of explosive and flexible material that influences the load of the interface is discussed emphatically.

Keywords： flexible material     explosive loading     load remodeling     numerical simulation    

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Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction Article

Xianhao Xu, Xueqin Lv, Shixiu Cui, Yanfeng Liu, Hongzhi Xia, Jianghua Li, Guocheng Du, Zhaofeng Li, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu

Engineering 2023, Volume 28, Issue 9,   Pages 166-178 doi: 10.1016/j.eng.2023.03.019

Abstract: As a proof-of-concept validation, we design an IPP metabolism remodeling strategy to improve the productionThus, we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally

Keywords： Terpenoids     Genetic circuits     Bacillus subtilis     Isoprene pyrophosphate    

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Title Author Date Type Operation

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Journal Article

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Journal Article

Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city

Mbakisya ONYANGO, Saliha Ammour MERABTI, Joseph OWINO, Ignatius FOMUNUNG, Weidong WU

Journal Article

A dynamic signal coordination control method for urban arterial roads and its application

Guo-jiang SHEN,Yong-yao YANG

Journal Article

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Journal Article

Contemporary coronary artery bypass grafting

David P. Taggart

Journal Article

Non-invasive continuous blood pressure monitoring: a review of current applications

Elena Chung, Guo Chen, Brenton Alexander, Maxime Cannesson

Journal Article

Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Journal Article

Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction

Xianhao Xu, Xueqin Lv, Shixiu Cui, Yanfeng Liu, Hongzhi Xia, Jianghua Li, Guocheng Du, Zhaofeng Li, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu

Journal Article